Insulin Resistance and Its Treatment by Thiazolidinediones
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چکیده
منابع مشابه
Insulin resistance and its treatment by thiazolidinediones.
Insulin resistance is a change in physiologic regulation such that a fixed dose of insulin causes less of an effect on glucose metabolism than occurs in normal individuals. The normal compensatory response to insulin resistance is an increase in insulin secretion that results in hyperinsulinemia. If the hyperinsulinemia is sufficient to overcome the insulin resistance, glucose regulation remain...
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Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We therefore generated mice with muscle-specific PPARgamma knockout (MuPPARgammaKO) using Cre/l...
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ژورنال
عنوان ژورنال: Recent Progress in Hormone Research
سال: 2001
ISSN: 0079-9963
DOI: 10.1210/rp.56.1.265